Evolution of diapause in the African turquoise killifish by remodeling ancient gene regulatory landscape
Param Priya Singh*, G Adam Reeves*, Kévin Contrepois, Katharina Papsdorf, Jason W Miklas, Mathew Ellenberger, Chi-Kuo Hu, Michael P Snyder, Anne Brunet
Cell, 2024
Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate
Yiwen R Chen*, Itamar Harel*, Param Priya Singh, Inbal Ziv, Eitan Moses, Uri Goshtchevsky, Ben E Machado, Anne Brunet, Daniel F Jarosz
Developmental Cell, 2024
Identification of protein aggregates in the aging vertebrate brain with prion-like and phase separation properties
Itamar Harel*, Yiwen R Chen*, Inbal Ziv, Param Priya Singh, Paloma Navarro Negredo, Uri Goshtchevsky, Wei Wang, Gwendoline Astre, Eitan Moses, Andrew McKay, Ben E Machado, Katja Hebestreit, Sifei Yin, Alejandro Sánchez Alvarado, Daniel F Jarosz, Anne Brunet
Cell Reports, 2024
Considerations for reproducible omics in aging research
Param Priya Singh*, Berenice A Benayoun*
Nature Aging, 2023
Chromatin Accessibility Profiling and Data Analysis using ATAC-seq in Nothobranchius furzeri
G. Adam Reeves, Param Priya Singh, Anne Brunet
Cold Spring Harbor Protocols, 2023
Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish
Bryan B Teefy, Ari Adler, Alan Xu, Katelyn Hsu, Param Priya Singh, Berenice A Benayoun
Genome Research, 2022
An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning
Andrew McKay, Emma K Costa, Jingxun Chen, Chi-Kuo Hu, Xiaoshan Chen, Claire Nicole Bedbrook, Rishad C Khondker, Mike Thielvoldt, Param Priya Singh, Tony Wyss-Coray, Anne Brunet
Elife, 2022
Vertebrate diapause preserves organisms long term through Polycomb complex members
Chi-Kuo Hu, Wei Wang, Julie Brind’Amour, Param Priya Singh, G Adam Reeves, Matthew C Lorincz, Alejandro Sánchez Alvarado, Anne Brunet
Science, 2020
Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells
Atousa Arbabian, Mircea Iftinca, Christophe Altier, Param Priya Singh, Hervé Isambert, Sylvie Coscoy
Channels, 2020
The genetics of aging: a vertebrate perspective
Param Priya Singh*, Brittany A Demmitt*, Ravi D Nath*, Anne Brunet
Cell, 2019
OHNOLOGS v2: A comprehensive resource for the genes retained from whole genome duplication in vertebrates
Param Priya Singh, Hervé Isambert
Nucleic Acids Research, 2019
Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses
Bérénice A Benayoun, Elizabeth A Pollina, Param Priya Singh, Salah Mahmoudi, Itamar Harel, Kerriann M Casey, Ben W Dulken, Anshul Kundaje, Anne Brunet
Genome Research, 2019
The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development
Josiah T Wagner, Param Priya Singh, Amie L Romney, Claire L Riggs, Patrick Minx, Steven C Woll, Jake Roush, Wesley C Warren, Anne Brunet, Jason E Podrabsky
BMC Genomics, 2018
Progranulin, lysosomal regulation and neurodegenerative disease
Aimee W Kao, Andrew McKay, Param Priya Singh, Anne Brunet, Eric J Huang
Nature Neuroscience, 2017
Learning causal networks with latent variables from multivariate information in genomic data
Louis Verny, Nadir Sella, Séverine Affeldt, Param Priya Singh, Hervé Isambert
PLOS Computational Biology, 2017
The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan
Dario R Valenzano*, Bérénice A Benayoun*, Param Priya Singh*, Elisa Zhang, Paul D Etter, Chi-Kuo Hu, Mathieu Clément-Ziza, David Willemsen, Rongfeng Cui, Itamar Harel, Ben E Machado, Muh-Ching Yee, Sabrina C Sharp, Carlos D Bustamante, Andreas Beyer, Eric A Johnson, Anne Brunet
Cell, 2015
A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate
Itamar Harel, Bérénice A Benayoun, Ben Machado, Param Priya Singh, Chi-Kuo Hu, Matthew F Pech, Dario R Valenzano, Elisa Zhang, Sabrina C Sharp, Steven E Artandi, Anne Brunet
Cell, 2015
Identification of ohnolog genes originating from whole genome duplication in early vertebrates, based on synteny comparison across multiple genomes
Param Priya Singh, Jatin Arora, Hervé Isambert
PLOS Computational Biology, 2015
Human dominant disease genes are enriched in paralogs originating from whole genome duplication
Param Priya Singh, Séverine Affeldt, Giulia Malaguti, Hervé Isambert
PLOS Computational Biology, 2014
On the retention of gene duplicates prone to dominant deleterious mutations
Giulia Malaguti, Param Priya Singh, Hervé Isambert
Theoretical Population Biology, 2014
On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates
Param Priya Singh*, Séverine Affeldt*, Ilaria Cascone, Rasim Selimoglu, Jacques Camonis, Hervé Isambert
Cell Reports, 2012
Case for an RNA-prion world: a hypothesis based on conformational diversity
Param Priya Singh, Anirban Banerji
Journal of Biological Physics, 2011
